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Exclusion Criteria​

1) ASPECTS Less than 8​

2) The following depend on the imaging modality of the participating site:​

  • NCCT + mCTA: Well demarcated hypodensity in the majority of the brain parenchyma supplied by the occluded vessel or absence of collaterals in the affected territory on the delayed phases of the mCTA​
  • OR​  NCCT + (m)CTA + CTP: Lack of core:penumbra mismatch​
  • OR​ MRI: Diffusion restriction in the majority of the brain parenchyma supplied by the occluded vessel; if MR perfusion is performed: lack of diffusion:perfusion mismatch​

3) Any evidence of intracranial hemorrhage on qualifying imaging​

4) Patients living in a nursing home or requiring daily nursing care or assistance with activities of daily living.​

5) Patient is unlikely to be able to complete follow-up or they are unlikely to achieve the primary outcome due to an underlying illness (eg end stage cancer, etc.).​

6) Pregnancy: female with positive urine or serum beta human chorionic gonadotropin (β-hCG) test​

7) Participation in another clinical therapeutic intervention trial ​