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Inclusion Criteria

  • Acute ischemic stroke clinically eligible for immediate EVT
  • Age ≥18 years at the date of randomization
  • Time from onset (or last-seen-well) to randomization <12 hours
  • Disabling stroke with baseline National Institutes of Health Stroke Scale (NIHSS) score >5 at the time of randomization OR NIHSS 3-5 with disabling deficit (eg. hemianopia, aphasia, loss of hand function) as determined by the attending physician in context of the patient’s life situation
  • Confirmed symptomatic and endovascularly treatable MeVO based on neurovascular non-invasive imaging (mCTA or MRA), at one or more of the following locations:
  • Clinical deficit commensurate with MeVO occlusion location.